📄🔓 #Zoonoses: 'Chapare Virus—An Emerging Hemorrhagic Fever Threat: A CBRNE Perspective on Preparedness and Biosecurity Risks' - an article on #ScienceOpen ➡️ https://www.scienceopen.com/hosted-document?doi=10.15212/ZOONOSES-2025-0039

#ChapareVirus #HemorrhagicFever #Biosecurity #ScienceMastodon

Chapare Virus—An Emerging Hemorrhagic Fever Threat: A CBRNE Perspective on Preparedness and Biosecurity Risks

<p xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="first" dir="auto" id="d6474661e192">Chapare virus (CHAV), an emerging Bolivian arenavirus causing severe hemorrhagic fever, provides a critical case study for rethinking pandemic preparedness in an era of escalating zoonotic threats. With its case-fatality rate exceeding 60% and documented human-to-human transmission, CHAV exemplifies the convergence of natural spillover risks and potential bioterrorism concerns, which warrant its classification alongside U.S. Centers for Disease Control and Prevention (CDC) category A priority pathogens. This study examines how military-derived Chemical, Biological, Radiological, Nuclear, and Explosive (CBRNE) frameworks, including syndromic surveillance networks and advanced biodetection technologies, might transform preparedness for high-consequence arenaviruses. Climate-driven rodent migration in South America exacerbates outbreak risks, and the absence of point-of-care diagnostics and approved therapeutics leaves global health systems vulnerable. We demonstrate how conflict-tested tools, such as portable genomic sequencers and North Atlantic Treaty Organization (NATO)-style biosurveillance protocols, could be repurposed for real-time CHAV monitoring in endemic regions. The analysis identifies urgent gaps in biosecurity policy, particularly regarding rodent-borne viruses, and proposes a dual-pathway strategy to strengthen One Health surveillance while integrating biodefense infrastructure to mitigate both natural outbreaks and intentional releases. This work underscores the imperative to bridge civilian and military preparedness paradigms for emerging zoonoses with pandemic potential. </p>

ScienceOpen

New Hemorrhagic Fever Emerges in the Democratic Republic of Congo #DRC, 50 die within 48 hours - An unknown illness first discovered in three children who ate a bat has rapidly killed more than 50 people in northwestern Congo over the past five weeks, health experts say. The interval between the onset of symptoms – which include fever, vomiting and internal bleeding – and death has been 48 hours in most cases and “that’s what’s really worrying,” said Serge Ngalebato, medical director of Bikoro Hospital, a regional monitoring center. These “hemorrhagic fever” symptoms are commonly linked to known deadly viruses, such as Ebola, dengue, Marburg and yellow fever, but researchers have ruled these out based on tests of more than a dozen samples collected so far. #pandemic #Africa #HemorrhagicFever #PublicHealth #epidemiology #virus

https://apnews.com/article/congo-mystery-unknown-illness-cd8b1fdcb3b2ed032968b2c6044dc6db

A mystery illness in Congo has killed more than 50 people hours after they felt sick

Health experts say an unknown illness first discovered in three children who ate a bat has rapidly killed more than 50 people in northwestern Congo over the past five weeks. A medical director of a regional monitory center says the interval between the onset of symptoms – which include fever, vomiting and internal bleeding – and death has been 48 hours in most cases and “that’s what’s really worrying.” These “hemorrhagic fever” symptoms are commonly linked to known deadly viruses, such as Ebola, dengue, Marburg and yellow fever, but researchers have ruled these out based on tests of more than a dozen samples collected so far. The latest disease outbreak in the Democratic Republic of Congo began on Jan. 21, with 419 cases recorded and 53 deaths.

AP News
Eurosurveillance | Volume 28, Issue 16

eurosurveillance.org is the online home of Eurosurveillance, Europe's journal on infectious disease surveillance, epidemiology, prevention and control.

Equatorial Guinea quarantines 200 after unknown hemorrhagic fever deaths

Equatorial Guinea has quarantined more than 200 people and restricted movement after an unknown illness causing hemorrhagic fever killed at least eight people, Health Minister Mitoha Ondo'o Ayekaba said on Friday as the government races to test samples.

Reuters