How do FBXL4 mutations lead to #encephalomyopathic #mtDNA depletion syndrome 13?

Hui Jiang et al find increased #mitochondrial loss and perinatal lethality in Fbxl4 KO mice due to increased levels of #mitophagy receptors #BNIP3 and NIX targeted by SCF-#FBXL4 #ubiquitin ligase

https://www.embopress.org/doi/10.15252/embj.2022113033