I'm really pleased to be able to share our preprint on structurally characterising the effects of NDUFS4 knockout on mouse complex I
https://www.biorxiv.org/content/10.1101/2023.07.17.549284v1

The NDUFS4 knockout in mouse is a model for patients with Leigh syndrome. We find that the NDUFS4 knockout is detrimental to the quantity, stability and activity of complex I in the mitochondria.

#cryoem #mitochondria #complexI @structbio