New independent preprint (AI-assisted, fully open + reproducible): a within-host HIV model in which a therapeutic interfering particle coupled to the latent reservoir is predicted to *assist* immune-mediated post-treatment control โ€” extending, not contradicting, Dodd & de Boer (2025). Illustrative modeling hypothesis, not a cure. Read / code / DOI: https://sethc555.github.io/hiv-aids-research/ #HIV #immunology #virology #compbio #mathbio
A reservoir-coupled therapeutic interfering particle can assist immune-mediated HIV-1 post-treatment control: a within-host modeling study

A within-host modeling study: a therapeutic interfering particle (TIP) coupled to latent-reservoir reactivation is predicted to assist immune-mediated HIV-1 post-treatment control โ€” extending, not contradicting, Dodd & de Boer (2025). Illustrative modeling hypothesis, not a cure.

Seth Cope โ€” HIV within-host modeling

I am deeply honored & thrilled to have been elected Vice President (& future 2028 President) of the ๐ˆ๐ง๐ญ๐ž๐ซ๐ง๐š๐ญ๐ข๐จ๐ง๐š๐ฅ ๐’๐จ๐œ๐ข๐ž๐ญ๐ฒ ๐จ๐Ÿ ๐๐ฎ๐š๐ง๐ญ๐ฎ๐ฆ ๐๐ข๐จ๐ฅ๐จ๐ ๐ฒ ๐š๐ง๐ ๐๐ก๐š๐ซ๐ฆ๐š๐œ๐จ๐ฅ๐จ๐ ๐ฒ #ISQPB

https://isqbp.org/

I look forward to serving this vibrant community of computational scientists #compchem #compbio #machinelearning #biophysics

Pinto et al. present SCINKD as a framework to identify unannotated sex chromosomes and curate diploid genome assemblies from a single individual.

๐Ÿ”— https://doi.org/10.1093/molbev/msag067

#evobio #molbio #compbio

Sex chromosome identification and genome curation from a single individual with SCINKD

Abstract. In most animal species, the sex-determining pathway is typically initiated by the presence/absence of a primary genetic cue at a critical point d

OUP Academic

Didelot et al. present the R package DiagnoDating for diagnosing issues in a reconstructed dated phylogeny, including outlier detection, posterior predictive checking and residual analysis.

๐Ÿ”— https://doi.org/10.1093/molbev/msag093

#evobio #molbio #compbio #phylogeny

DiagnoDating: diagnostics for dated phylogenies in microbial population genetics

Abstract. Microbial population genetic studies often involve the use of a dated phylogeny to show how the genomes are related over a relevant timescale. Ma

OUP Academic

Daniel Huson introduces displacement-optimized tanglegrams (DO-tanglegrams), a new approach that applies equally to trees and rooted phylogenetic networks, performing better than cophylo on trees and then NN-tanglegram on networks.

๐Ÿ”— https://doi.org/10.1093/molbev/msag066

#evobio #molbio #compbio

McArthur et al. present piqtree, an easy to use, open-source Python package that provides Python script-based control of IQ-TREEโ€™s phylogenetic inference engine.

๐Ÿ”— https://doi.org/10.1093/molbev/msag061

#evobio #molbio #compbio

@sishuowang & Meade introduce phyloHessian to enable the use of complex mixture substitution models in molecular dating. Empirical analysis of ancient symbiont lineages leads to a revised understanding of their host association origins.

๐Ÿ”— https://doi.org/10.1093/molbev/msag039

#evobio #molbio #compbio

Robbins, Liu & Kelly present RECUR, a method for identifying recurrent amino acid substitutions from multiple sequence alignments that is fast, easy to use, and scalable to thousands of sequences.

๐Ÿ”— https://doi.org/10.1093/molbev/msag036

#evobio #molbio #compbio

Deng et al. present TreeProfiler, a tool for automated annotation and interactive exploration of hundreds of features along large gene and species trees, with seamless summarization of mapped traits at internal nodes.

๐Ÿ”— https://doi.org/10.1093/molbev/msag028

#evobio #molbio #compbio

Martรญ-Gรณmez et al. developed gpmap-tools, integrating models for inference, phenotypic imputation, and error estimation from multiplex assays of variant effect data or natural sequences in the presence of genetic interactions.

๐Ÿ”— https://doi.org/10.1093/molbev/msag023

#evobio #molbio #compbio