StructBiolCommunicationsThe crystallographic structures of two antigen-unknown ultralong antibodies, D08 and BLV5B8, are compared with those of synthetic antibodies produced by recombinant chain-exchanged variants #Ultralong #Immunoglobulin #Antibody https://t.co/s5scyc2Pi8
The impact of exchanging the light and heavy chains on the structures of bovine ultralong antibodies
Complementary-determining region 3 (CDR3) of the light chain interacts with the extended CDR3 of the paired heavy chain in bovine ultralong antibodies. Exchanging light chains between two different ultralong antibodies induced a small axial twist in the CDR3H β-ribbon stalk region; however, comparative crystallographic interface analysis indicates that the ultralong loops have flexibility and their positioning is affected by crystal packing.
Matt Willemsen