TseVF-TsiVF, a novel bacteriolytic effector-immunity pair of #Vibrio fluvialis VflT6SS2, provides a fitness advantage in microbial competition
https://www.sciencedirect.com/science/article/pii/S2666517426000076 #OpenAccess #T6SS #Microbiology
The secretion mechanisms of many type VI secretion system (T6SS) effectors in Gram-negative bacteria remain unclear. This study identifies a new class of T6SS effectors, which can harbor either one or two toxic domains, and use WHIX as a secretion motif.
Vibrio coralliilyticus is a pathogen of coral and shellfish that is becoming more virulent as ocean temperatures rise, causing significant damage. This study shows that V. coralliilyticus has two type VI secretion systems (T6SSs) that are activated at high temperatures; one targets bacterial competitors, while the other launches up to 9 novel toxins against eukaryotic hosts like shrimps.
Proud to share our new paper on RIX, a delivery domain defining a new class of polymorphic #T6SS effector in #Vibrio.
Bacteria use the type VI secretion system (T6SS) to deliver toxic effectors into bacterial or eukaryotic cells. Here, Kanarek et al. identify a protein domain, RIX, that defines a class of polymorphic T6SS effectors with antibacterial and anti-eukaryotic toxic domains, and that enables T6SS-mediated delivery of other effectors.
Type VI secretion systems: Weapons of #bacterial destruction.
https://phys.org/news/2023-04-vi-secretion-weapons-bacterial-destruction.html
PLOS Biology
David Ojcius
Dor Salomon
CellBioNews
Akos T Kovacs