Hao YinEffects of #Aneuploidy on cell behavior & function
Cause:
ROS
DNA replication
mitosis
mechanical confinement
Direct dosage + secondary Effect:
Redox, bioenergetic, proteostasis, Osmosis
Cancer, Aging
Dr Rong Li & Jin Zhu Nature Reviews MCB 2023
https://www.nature.com/articles/s41580-021-00436-9
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Any evidence on #Aneuploidy in cardiovascular biology?
From Abraham Aviv lab @ATHjournal 2001
Age-dependent aneuploidy & telomere length of the human vascular endothelium
https://www.atherosclerosis-journal.com/article/S0021-9150(01)00506-8/fulltext
Tetrasomy Chr6 Chr16
Loss ChrY
Aneuploidy in cardiovascular diseases?🧐
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Mice with #SpindleAssemblyCheckpoint protein BubR1 deficiency have a spectrum of vascular defects
Vascular BubR1 1/3
Aging-Associated Vascular Phenotype in Mutant Mice With Low Levels of BubR1
Dr. Jan van Deursen lab @StrokeAHA_ASA 2007
https://www.ahajournals.org/doi/10.1161/01.STR.0000257967.86132.01
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Vascular BubR1 2/3
BubR1 Insufficiency Inhibits #NeointimalHyperplasia Through Impaired Vascular #SmoothMuscleCell Proliferation in Mice
Dr. Takuya Matsumoto lab @atvbahajournals 2014
https://www.ahajournals.org/doi/10.1161/ATVBAHA.114.304737
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Vascular BubR1 3/3
BubR1 insufficiency impairs #Angiogenesis in aging and in experimental critical limb ischemic mice
Dr. Takuya Matsumoto lab @JVascSurg 2018
https://www.jvascsurg.org/article/S0741-5214(17)32041-4/fulltext
Effects of aneuploidy on cell behaviour and function - Nature Reviews Molecular Cell Biology
Aneuploidy affects organisms from early development through to aging and is a cause of pregnancy loss and cancer. Recent studies have increased our understanding of its mechanisms and how it can be both beneficial and detrimental to cells and organisms, depending on the karyotype and external cues. These insights shed light on its roles in human pathogenesis and on genome evolution.