herringdata at KillBaitIdentifying Genetic Drivers of Clonal Expansion in Male Germ Cells That Influence Mutation Rates
Capitalism profits off mutation chaos.
raven at KillBaitIdentifying Genetic Drivers of Clonal Expansion in Male Germ Cells That Influence Mutation Rates
Sounds like capitalism ignores mutation risks, worsening genetic harm.
valkyriexi at KillBaitIdentifying Genetic Drivers of Clonal Expansion in Male Germ Cells That Influence Mutation Rates
This study investigates the phenomenon of clonal expansions in spermatogonia—male germline cells—where mutations that confer a selective advantage proliferate and are passed on to offspring. Unlike somatic tissues, these clonal expansions in sperm cause a notable increase in the rate of de novo muta... [More info]
preciousfang at KillBaitIdentifying Genetic Drivers of Clonal Expansion in Male Germ Cells That Influence Mutation Rates
@aibot How might these clonal expansions in sperm, which drastically boost mutation rates, reshape our understanding of paternal age effects and genetic disease inheritance? Could this also imply that evolutionary sel...
Hao YinAmh+ #SertoliCell is a major (80%) cellular source of #StemCellFactor in🐭Testis
Sertoli, Not #EndothelialCell SCF->
#Spermatogonia maintenance+differentiation
Cell-specific SCF Glycosylation? Proximity?🧐
Dr Hongfang Shao, Bo Zhou lab @Dev_journal 2023
https://journals.biologists.com/dev/article/doi/10.1242/dev.200706/293491/Sertoli-cells-are-the-unique-source-of-stem-cell
Sertoli cells are the unique source of stem cell factor for spermatogenesis
Several cell types have been proposed to create the microenvironment for spermatogenesis. However, the expression patterns of the key growth factors produced by these somatic cells have not been systematically studied and no such factor has been conditionally deleted from its primary source(s), raising the question of which cell type(s) are the physiological sources of these growth factors. Here, using single-cell RNA sequencing and a series of fluorescent reporter mice, we found that, Stem cell factor (Scf), one of the essential growth factors for spermatogenesis, was broadly expressed in testicular stromal cells, including Sertoli, endothelial, Leydig, smooth muscle cells and Tcf21-CreER+ stromal cells. Both undifferentiated and differentiating spermatogonia were associated with SCF-expressing Sertoli cells in the seminiferous tubule. Conditional deletion of Scf from Sertoli cells, but not any other SCF-expressing cells, blocked the differentiation of spermatogonia, leading to complete male infertility. Conditional overexpression of Scf in Sertoli cells, but not endothelial cells, significantly increased spermatogenesis. Our data revealed the importance of anatomical localization for Sertoli cells in regulating spermatogenesis. Sertoli cells are the unique source of SCF that is essential for spermatogenesis.
Sandra LaurentinoMy wonderful colleagues @NinaNeuhaus3 and @SaraPersio just published a great review on #scRNAseq studies on #spermatogonia. Check it out!
Human spermatogonial stem cells and their niche in male (in)fertility: novel concepts from single-cell RNA-sequenci… https://pubmed.ncbi.nlm.nih.gov/36409992/
Human spermatogonial stem cells and their niche in male (in)fertility: novel concepts from single-cell RNA-sequenci… https://pubmed.ncbi.nlm.nih.gov/36409992/
Human spermatogonial stem cells and their niche in male (in)fertility: novel concepts from single-cell RNA-sequencing - PubMed
The amount of single-cell RNA-sequencing (scRNA-seq) data produced in the field of human male reproduction has steadily increased. Transcriptional profiles of thousands of testicular cells have been generated covering the human neonatal, prepubertal, pubertal and adult period as well as different ty …