SiDock@home #BOINC project opens vote for the next target:
1) SARS-CoV-2 main protease (3CLpro) further studies
"This is a crucial therapeutic target against SARS-CoV-2. 3CLpro (cysteine protease; EC 3.4.22.69) in particular is crucial for the cleavage of coronavirus polyproteins to form mature non-structural proteins that are themselves essential for viral replication mechanisms. We still need much more research on this target towards new more potent inhibitors."
2) Ebolavirus glycoprotein (GP)
"Ebola virus is a dangerous pathogen to humans and this target could be a perfect study case for PPI-type drug design scenario. The EBOV glycoprotein (GP) is the only virally expressed protein on the virion surface and is critical for attachment to host cells and catalysis of membrane fusion."
3) Swine acute diarrhea syndrome coronavirus (SADS-CoV PLpro)
"This target would enable us to study the design on multiple related viral targets. Swine acute diarrhea syndrome coronavirus (SADS-CoV), a newly emerging enteric coronavirus, is considered to be associated with swine acute diarrhea syndrome (SADS) which has caused significantly economic losses to the porcine industry. The pathogen indicates towards host-jump potential."
Можно проголосовать, на поиск лекарства от какой болезни направить 60 терафлопс вычислительной мощности:
1) #COVID19
2) Лихорадка #Эбола
3) Острая свиная диарея (#SADS)
Good to see slow but steady progress being made on next-gen #covid #vaccines. https://www.cidrap.umn.edu/covid-19/codagenix-announces-promising-findings-intranasal-covid-vaccine
Also check out #sidock. They are an intl scientific collaboration using the computers of volunteers to discover a shelf-stable patent-free antiviral for covid using the #boinc platform. Their software runs on Windows, MacOS, and Linux, no PhD required https://sidock.si/sidock/ #projectnextgen
Compute4Change
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