Cardiac Repair Promoted by Cyclin A2, Potential Heart Transplant Alternative

In a new study published in Nature Regenerative Medicine titled, “Cyclin A2 induces cytokinesis in human adult cardiomyocytes and drives reprogramming in mice,” researchers from Icahn School of Medicine at Mount Sinai have shown that the gene for Cyclin A2 (CCNA2), which turns off after birth in humans, can promote cardiac repair in adult human cardiomyocytes, providing a new avenue to treat heart injury and failure as an alternative to heart transplants or implanted cardiac devices.