Show threadBérénice A. BenayounJan 11, 2023
We are glad that the editorial team at #TranslationalMedicineOfAging and the peer-reviewers agreed that these were important results to disseminate to the #ReproAging research community.
We also thank @[email protected] for supporting our work! @[email protected] 5/5
Show threadBérénice A. BenayounJan 11, 2023
As noted before, although we are disappointed that these mice cannot be used to effectively model menopausal states, we hope our observations will be useful to the #ReproAging community and avoid unnecessary waste of animals/time/resources by other labs. 4/5
Show threadBérénice A. BenayounJan 11, 2023
We confirmed that the #KOMP allele should correspond to a null allele (confirmed by Sanger🧬), but it seems that the wild-type allele is compensating in this 🐁 strain, leading to normal Fshr expression, ovarian function and absence of #ReproAging phenotype.
3/5
Show threadBérénice A. BenayounJan 11, 2023
Previous tweetorial on the preprint below - briefly, we did not observe any indication of accelerated #ReproAging in the #KOMP Fshr allele, contrary to previous work (on a distinct allele), based on breeding, endocrine markers and histology.
2/5 https://twitter.com/BBParis1984/status/1578525667620098049?s=20&t=kkhCl_hXSu3SGPri8ReUmw
Bérénice A. Benayoun, PhD on Twitter

“The lab has an unusual (but important) preprint out today... With negative results which we believe need to be disseminated to the community: "Lack of accelerated ovarian aging in a follicle-stimulating hormone receptor haploinsufficiency model" a 🧶 1/n https://t.co/KK8krIvUuU”

Twitter
Show threadBérénice A. BenayounJan 2, 2023
We hope that this study will be a useful resource for #ReproAging research and #TE Biology!
We also thank @[email protected], our🐠🧙‍♂️#AriAdler and talented #qbio and #mcb undergrad #AlanXu and #KatelynHsu for their help on this study! 9
Show threadBérénice A. BenayounJan 2, 2023
We were curious about how #TEs would be impacted by #ReproAging, since #TE reactivation is frequent during somatic aging. Because of transgenerational mutagenic potential, dedicated safeguards evolved to keep #TEs in check in the #germline, notably through the #PIWI pathway. 3/n
Bérénice A. BenayounJan 2, 2023
Really excited to share our latest work, on deciphering #TE control 🧬 during #ReproAging ♀️♂️ in #AfricanTurquoiseKillifish 🐟 [ATK], online today at @[email protected]! This was spearheaded by talented #DrBryanTeefy in the lab. @[email protected] A 🧵 1/n
https://genome.cshlp.org/content/early/2022/12/28/gr.277301.122.abstract
Dynamic regulation of gonadal transposon control across the lifespan of the naturally short-lived African turquoise killifish

An international, peer-reviewed genome sciences journal featuring outstanding original research that offers novel insights into the biology of all organisms