Bérénice A. BenayounWe confirmed that the #KOMP allele should correspond to a null allele (confirmed by Sanger🧬), but it seems that the wild-type allele is compensating in this 🐁 strain, leading to normal Fshr expression, ovarian function and absence of #ReproAging phenotype.
3/5
Previous tweetorial on the preprint below - briefly, we did not observe any indication of accelerated #ReproAging in the #KOMP Fshr allele, contrary to previous work (on a distinct allele), based on breeding, endocrine markers and histology.
2/5 https://twitter.com/BBParis1984/status/1578525667620098049?s=20&t=kkhCl_hXSu3SGPri8ReUmw
2/5 https://twitter.com/BBParis1984/status/1578525667620098049?s=20&t=kkhCl_hXSu3SGPri8ReUmw
Bérénice A. Benayoun, PhD on Twitter
“The lab has an unusual (but important) preprint out today... With negative results which we believe need to be disseminated to the community: "Lack of accelerated ovarian aging in a follicle-stimulating hormone receptor haploinsufficiency model" a 🧶 1/n https://t.co/KK8krIvUuU”