Pereda LabLiao and Shattil
"Talin, a Rap1 effector for integrin activation at the plasma membrane, also promotes Rap1 activity by disrupting sequestration of Rap1 by SHANK3"
#paper_alert
Min et al.,
From Static to Dynamic Structures: Improving Binding Affinity Prediction with Graph-Based Deep Learning
https://onlinelibrary.wiley.com/doi/10.1002/advs.202405404
Dynaformer predicts the binding affinities by learning the geometric characteristics of the protein-ligand interactions from the MD trajectories.
#paper_alert
Cellular stiffness sensing through talin 1 in tissue mechanical homeostasis
Chanduri et al
https://www.science.org/doi/10.1126/sciadv.adi6286
Cellular stiffness sensing through talin 1 in tissue mechanical homeostasis
Chanduri et al
https://www.science.org/doi/10.1126/sciadv.adi6286
#paper_alert #review
The desmosome comes into focus
Navaneetha Krishnan Bharathan
Alexa L. Mattheyses
Andrew P. Kowalczyk
@JCellBiol
https://rupress.org/jcb/article/223/9/e202404120/276896
The desmosome comes into focus
Navaneetha Krishnan Bharathan
Alexa L. Mattheyses
Andrew P. Kowalczyk
@JCellBiol
https://rupress.org/jcb/article/223/9/e202404120/276896
#paper_alert
αMI-domain of integrin Mac-1 binds the cytokine pleiotrophin using multiple mechanisms
Nguyen et al
https://www.cell.com/structure/abstract/S0969-2126(24)00139-4
@structure_cp
PTN’s N-terminal domain binds αMI-domains using a unique site on αMI-domain
PTN’s C-terminal domain binds active αMI-domain through the MIDAS metal
Cryo-EM architecture of a near-native stretch-sensitive membrane microdomain.
Kefauver et al.
Structure of near-native eisosomes helical tubules made up of BAR-domain proteins Pil1 and Lsp1
https://www.nature.com/articles/s41586-024-07720-6
#paper_alert
Kefauver et al.
Structure of near-native eisosomes helical tubules made up of BAR-domain proteins Pil1 and Lsp1
https://www.nature.com/articles/s41586-024-07720-6
#paper_alert
Cryo-EM architecture of a near-native stretch-sensitive membrane microdomain - Nature
Cryo-electron microscopy, in vitro reconstitution and molecular dynamics simulations provide insight into the architecture of a plasma membrane microdomain in yeast, the organization and dynamics of the membrane lipids within this microdomain and how it responds to mechanical stress.
#paper_alert
Liu et al
Cortactin stabilizes actin branches by bridging activated Arp2/3 to its nucleated actin filament
Cortactin binds to the daughter actin filament. Cortactin preferentially binds to activated Arp3 and stabilizes F-actin-like interface of activated Arp3
Congrats to the Way and Moores labs
Cortactin stabilizes actin branches by bridging activated Arp2/3 to its nucleated actin filament - Nature Structural & Molecular Biology
Liu et al. show how cortactin stabilizes Arp2/3 actin branches by binding the daughter filament. It stabilizes the interface of activated Arp3 with the first actin subunit of the new filament, and its central repeats extend along successive daughter-filament subunits.
#paper_alert
Engineering an artificial catch bond using mechanical anisotropy
Liu, Z., Liu, H., Vera, A.M. et al. Nat Commun 15, 3019 (2024).
Engineering an artificial catch bond using mechanical anisotropy - Nature Communications
Catch bonds are unique protein-protein interactions where the bond lifetime increases under external pulling forces. Here, the authors engineer an artificial catch bond based on a non-catch bonding human gut bacterial adhesion protein complex.
High-throughput prediction of protein conformational distributions with subsampled AlphaFold2
Monteiro da Silva et el
https://www.nature.com/articles/s41467-024-46715-9
And the link to the Colab notebook
https://t.co/EJ92Mmocol
High-throughput prediction of protein conformational distributions with subsampled AlphaFold2 - Nature Communications
Protein dynamics, crucial for life, are difficult and expensive to predict. This study shows that AI-based structure prediction methods can be modified for rapidly predicting the conformational landscapes of proteins, with strong correlations with experimentally-measured relative state populations.
#paper_alert
The focal adhesion protein talin is a mechanically gated A-kinase anchoring protein
M. Kang, Y. Otani, Y. Guo, J. Yan, B. Goult and AK. Howe
This work shows that PKA binds yo talin1 rod domain in a force-dependent manner, which couples cellular tension to cellular communication
https://www.pnas.org/doi/10.1073/pnas.2314947121
Explained in the following video by Ben Goult
https://m.youtube.com/watch?v=J42J5dzMCdY