Genetic changes sustaining the development of #CancerOfUnknownPrimary (CUP) remain elusive. New study reports a novel activating mutation of the #AxonGuidance gene #PLXNB2 that sustains proliferative autonomy and confers invasive properties to CUP stem cells, in EGFR-dependent manner.

By E. Giraudo, L. Tamagnone & colleagues

👉 https://doi.org/10.15252/emmm.202216104