Albert Cardona"Thalamic activation of the visual cortex at the single-synapse level", Chen et al. 2026.
https://www.science.org/doi/full/10.1126/science.aec9923
There was earlier work using a much coarser technique which found the same result:
"Specificity of monosynaptic connections from thalamus to visual cortex", Reid and Alonso, 1995.
https://www.nature.com/articles/378281a0
Compare figure 3 in Reid & Alonso 1995 with Fig 5E in Chen et al. 2026.
But as Chen et al. 2026 says:
"Earlier experiments that used paired recordings of an orientation-selective L4 neuron in the cat visual cortex and a corresponding dLGN cell (5 [Reid and Alonso, 1995]) suggested, but could not prove, a synaptic connectivity scheme consistent with the H&W model. Our approach enabled the identification and characterization of nearly the complete set of active dLGN synaptic inputs to a single orientation-selective L4 neuron. The spatial alignment of receptive field centers of dLGN inputs matched the preferred orientation of the corresponding neuron. Thus, our findings directly validate core predictions of the connectivity proposed by the H&W [Hubel and Wiesel's] model."
By the way, Clay Reid was a trainee of H&W.