Clinical evidence “Russian flu” pandemic of 1889-1891 might have been a coronavirus pandemic
Contemporary medical reports from Britain and Germany on patients suffering from a pandemic infection between 1889 and 1891, which was historically referred to as the Russian flu, share a number of characteristics with COVID-19.
Fifteen years ago, the discussion of the agent responsible took a new turn with an unexpected observation from virologists working at KU Leuven in Belgium. They sequenced the human coronavirus OC43 (HCoV-OC43), and showed that it shared very high nucleotide sequence identity with bovine coronavirus (BCoV).
Notably, with an estimated 4.3 × 10-4 substitutions per site per year, the time to the most recent common ancestor of HCoV-OC43 and BCoV was dated by three methods to 1891, 1873 and 1890.
https://sfamjournals.onlinelibrary.wiley.com/doi/full/10.1111/1751-7915.13889
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