#Mayaro Virus: An Emerging #Alphavirus in the #Americas https://www.mdpi.com/1999-4915/16/8/1297
Overall, MAYV remains a neglected arbovirus due to its limited area of transmission. However, with the potential of its urbanisation and expanding circulation, the threat MAYV poses to global health cannot be overlooked.
Mayaro Virus: An Emerging Alphavirus in the Americas
Mayaro virus (MAYV) is an arbovirus first isolated in Trinidad and Tobago in 1954. MAYV is the causative agent of Mayaro fever, which is characterised by high fever, maculopapular rash, myalgia and arthralgia. The potential for chronic arthralgia is of particular clinical concern. Currently, MAYV outbreaks are restricted to South and Central America, with some cases reported in Africa as well as several imported cases in Europe. However, in recent years, MAYV has become a growing global concern due to its potential to emerge into urban transmission cycles. Challenges faced with diagnostics, as well as a lack of specific antivirals or licensed vaccines further exacerbate the potential global health threat posed by MAYV. In this review, we discuss this emerging arboviral threat with a particular focus on the current treatment and vaccine development efforts. Overall, MAYV remains a neglected arbovirus due to its limited area of transmission. However, with the potential of its urbanisation and expanding circulation, the threat MAYV poses to global health cannot be overlooked. Further research into the improvement of current diagnostics, as well as the development of efficacious antivirals and vaccines will be crucial to help prevent and manage potential MAYV outbreaks.
That's the 4th time we've visited Trinidad and Tobago 🇹🇹
The last time was 1 month, 0 days ago : Grace Fellowship Family Church in #Mayaro - https://mastodon.social/@pilgrimsonline/112704591486302498
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5/6
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Evolutionary #Profile of #Mayaro Virus in the #Americas: An #Update into #Genome Variability https://www.mdpi.com/1999-4915/16/5/809
These results provide information for a better understanding of genotypes circulating in the Americas.
Evolutionary Profile of Mayaro Virus in the Americas: An Update into Genome Variability
The Mayaro virus (MAYV) is an arbovirus with emerging potential, though with a limited understanding of its epidemiology and evolution due to the lack of studies and surveillance. Here, we investigated 71 MAYV genome sequences from the Americas available at GenBank and characterized the phylogenetic relationship among virus strains. A phylogenetic analysis showed that sequences were grouped according to the genotypes L, D, and N. Genotype D sequences were closely related to sequences collected in adjacent years and from their respective countries, suggesting that isolates may have originated from circulating lineages. The coalescent analysis demonstrated similar results, indicating the continuous circulation of the virus between countries as well. An unidentified sequence from the USA was grouped with genotype D, suggesting the insertion of this genotype in the country. Furthermore, the recombination analysis detected homologous and three heterologous hybrids which presented an insertion into the nsP3 protein. Amino acid substitutions among sequences indicated selective pressure sites, suggesting viral adaptability. This also impacted the binding affinity between the E1–E2 protein complex and the Mxra8 receptor, associated with MAYV entry into human cells. These results provide information for a better understanding of genotypes circulating in the Americas.
The Coordinating Research on Emerging Arboviral Threats Encompassing the Neotropics (CREATE-NEO)
<p class="first" id="d2825654e200">Arthropod-borne viruses, such as dengue, Zika, and Mayaro, are emerging at an accelerating
rate in the neotropics. The
<b>C</b>oordinating
<b>R</b>esearch on
<b>E</b>merging
<b>A</b>rboviral
<b>T</b>hreats
<b>E</b>ncompassing the
<b>Neo</b>tropics (CREATE-NEO) project, a part of the NIH-funded Centers for Research in Emerging
Infectious Diseases (CREID) network provides a nimble and flexible network of surveillance
sites in Central and South America coupled with cutting-edge modeling approaches to
anticipate and counter these threats to public health. Collected data and generated
models will be utilized to inform and alert local, regional, and global public health
agencies of enzootic arboviruses with a high risk of spillover, emergence, and transmission
among humans, and/or international spread. CREATE-NEO builds capacity
<i>in situ</i> to anticipate, detect, and respond to emerging arboviruses at the point of origin,
thereby maximizing the potential to avert full-blown emergence and widespread epidemics.
</p>
Giuseppe Michieli
Places of worship
daniel