ChannelomicsMechanism of conductance control and neurosteroid binding in NMDA #IonChannel receptors | Nature
Sorry it is paywalled…. But look at the beautiful channels 🥲
Substrate stiffness attenuates cardiomyocyte depolarization slope via sodium channel modulation (Increased stiffness of the substrate causes the dysfunction of Nav1.5 #Ionchannel kinetics) https://www.sciencedirect.com/science/article/abs/pii/S0003986125003820
Aberrant HCN4 #ionchannel expression: Impacts on neuronal excitability and implications for epilepsy pathogenesis - Spyrou - British Journal of Pharmacology
Paywalled
https://bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.70218
Massive reduction of RyR1 #Ionchannel in muscle spindles of mice carrying recessive Ryr1 mutations alters proprioception and causes scoliosis - Ruiz - The Journal of Physiology
https://physoc.onlinelibrary.wiley.com/doi/10.1113/JP287832?af=R
Augmenting AMPA #IonChannel signaling after spinal cord injury increases ependymal-derived neural stem/progenitor cell migration and promotes functional recovery - Nature Neuroscience
A polycyclic scaffold identified by structure-based drug design effectively inhibits the human P2X7 #IonChannel receptor - Nature Communications
Distinctive GABA A #Ionchannel receptor subunit expression modulates cell specific EMT and functional responses in glioblastoma breast and ovarian cancer - Scientific Reports
https://www.nature.com/articles/s41598-025-18894-y
https://www.nature.com/articles/s41598-025-18894-y
Calmodulin binding is required for calcium mediated TRPA1 #IonChannel desensitization | Nature Communications
A conserved mechanism of LRRC8 #ionchannel inhibition by two structurally distinct drugs | Communications Biology https://www.nature.com/articles/s42003-025-08795-1
Open access
Open access
ASIC #ionchannel currents in cultured primate retinal amacrine/ganglion cells - Saafir - 2025 - Physiological Reports - Wiley Online Library https://physoc.onlinelibrary.wiley.com/doi/10.14814/phy2.70290?af=R
