#TIL Gas6 is a senoprotein implicated in vascular and neurological aging. It is a vitamin K dependent protein (VKDP); carboxylation state affects its function.
To learn more I searched Google on 'Gas6 sex differences'; here is a link to the AI overview -
https://share.google/aimode/zlzgUU1tV1nm3P8dB
“To test their findings, the researchers isolated a protein associated with aging in the aortas of mice, and injected it into young mice to observe the results. ..."
The senoprotein tested was Gas6; it is a vitamin K dependent protein and it's activities are dependent on carboxylation. Unfortunately the original research article * is paywalled, so no details on carboxylation ...
* Comprehensive human proteome profiles across a 50-year lifespan reveal aging trajectories and signatures [2025]
https://doi.org/10.1016/j.cell.2025.06.047
Rhyothemis