Millions are Taking a Drug that Falls Short of its Promise to Lower Risk of #HeartAttack

“While #Fibrates such as #Gemfibrozil (#Lopid) and #Fenofibrate are proven to lower triglyceride levels, which can serve as a biomarker for #Cardiovascular disease risk, several major clinical studies from the past 20 years have failed to show a benefit of #fenofibrates over and above statins in further reducing #heart-related events.”

#FDA
https://medcitynews.com/2024/09/millions-are-taking-a-drug-that-falls-short-of-its-promise-to-lower-risk-of-heart-attack/

#Fibrates and #Kidney function

Is it

- glom hemodynamics
- increased creat production
- decreased creat tubular secretion

Nice discussion in the NEJM correspondence https://www.nejm.org/doi/full/10.1056/NEJMc2216470 with useful citations for a deeper dive for those interested!