StructBiolCommunicationsThe structure of FadD23 from M. tuberculosis complexed with the general inhibitor PhU-AMS sheds light on the design of inhibitors of FadD23 and of fatty acyl-AMP ligases @IUCr #MycobacteriumTuberculosis #Sulfolipid1Synthesis #FattyAcylAMPLigase https://doi.org/10.1107/S2053230X23005836
Structural basis for the development of potential inhibitors targeting FadD23 from Mycobacterium tuberculosis
The crystal structure of M. tuberculosis FadD23 complexed with the inhibitor 5′-O-[N-(11-phenoxyundecanoyl)sulfamoyl]adenosine was solved at 2.64 Å resolution and compared with similar three-dimensional structures. It is proposed that the inhibitor blocks substrate transfer from FadD23 to polyketide synthase 2.