Leibniz-HKIThe first out of 4 publications honored with the 2024 medac Research Award uncovered how #Ece1 controls the release of #candidalysin in Candida albicans, enabling fungal infections.
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Secretion of the fungal toxin candidalysin is dependent on conserved precursor peptide sequences - Nature Microbiology
The Candida albicans toxin, candidalysin, is embedded in an unusual conserved precursor peptide sequence (Ece1). The precursor is not required to block premature pore-forming toxicity, but rather to prevent candidalysin auto-aggregation.