Show threadChristian MayerJul 8, 2025

During corticogenesis, progenitor competence changes over time — generating distinct excitatory neuron types.

But it turns out that in inhibitory lineages, progenitors retain stable differentiation competence. Instead, temporal progression alters maturation dynamics.

#NewsMayerlab #Corticogenesis #PatchClamp

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PLOS BiologyAug 19, 2024
Arl2 regulates asymmetric division in fly neural stem cells via control of #microtubule growth. @HongyanWang9 &co show that, in mammalian #cortex, Arl2 binds to Cdk5rap2 to control microtubule growth, so regulating #corticogenesis #PLOSBiology https://plos.io/4dqDo5q
Arl2 GTPase associates with the centrosomal protein Cdk5rap2 to regulate cortical development via microtubule organization

Arl2 regulates asymmetric division in fly neural stem cells through the control of microtubule growth. This study shows that, during mammalian cortical development, Arl2 associates with Cdk5rap2 to control microtubule growth, thereby regulating corticogenesis.