Brent StockwellOur first paper of 2025! We identified viral-selective, non-covalent inhibitors of the sarscov2 #3CL main #protease using a DNA-encoded library, and optimized them using x-ray crystallography. https://www.nature.com/articles/s41467-024-55421-5?utm_source=rct_congratemailt&utm_medium=email&utm_campaign=oa_20250103&utm_content=10.1038/s41467-024-55421-5
Development of small molecule non-covalent coronavirus 3CL protease inhibitors from DNA-encoded chemical library screening - Nature Communications
Due to the limited efficacy of vaccines against SARS-CoV-2 and resistance to current therapies additional anti-viral therapeutics with pan-coronavirus activity are of high interest. Here, the authors screened 2.8 billion compounds from a DNA-encoded chemical library and identified small molecules that are non-covalent inhibitors targeting the conserved 3CL protease of SARS-CoV-2 and other coronaviruses.