Identification of naturally occurring #drug-resistant #mutations of #SARS-CoV-2 papain-like #protease

Howard G. Smith MD, AM on Instagram: "Protease Blood Test Signals Pancreatic Cancer Pancreatic ductal carcinoma, a particularly deadly form of this dread cancer, emits a tell-tale enzymatic change that can help detect its presence earlier when it is more treatable. Cancer biologists at the Oregon Health & Science University have developed a blood test, dubbed the PAC-MANN, that detects this form of pancreatic cancer with an 85% accuracy for early-stage cases. The test quantitates changes in protease activity that accompany development and progression of this cancer and is also useful for monitoring treatment effectiveness and cancer recurrences. https://www.science.org/doi/10.1126/scitranslmed.adq3110 #pancreatic #cancer #protease #pacmann"

0 likes, 0 comments - drhowardsmithreports on February 21, 2025: "Protease Blood Test Signals Pancreatic Cancer Pancreatic ductal carcinoma, a particularly deadly form of this dread cancer, emits a tell-tale enzymatic change that can help detect its presence earlier when it is more treatable. Cancer biologists at the Oregon Health & Science University have developed a blood test, dubbed the PAC-MANN, that detects this form of pancreatic cancer with an 85% accuracy for early-stage cases. The test quantitates changes in protease activity that accompany development and progression of this cancer and is also useful for monitoring treatment effectiveness and cancer recurrences. https://www.science.org/doi/10.1126/scitranslmed.adq3110 #pancreatic #cancer #protease #pacmann".

Development of small molecule non-covalent coronavirus 3CL protease inhibitors from DNA-encoded chemical library screening - Nature Communications

Due to the limited efficacy of vaccines against SARS-CoV-2 and resistance to current therapies additional anti-viral therapeutics with pan-coronavirus activity are of high interest. Here, the authors screened 2.8 billion compounds from a DNA-encoded chemical library and identified small molecules that are non-covalent inhibitors targeting the conserved 3CL protease of SARS-CoV-2 and other coronaviruses.

Infectious #parvovirus B19 circulates in the #blood coated with active host #protease inhibitors

Source: Nature Communications, AbstractThe lack of a permissive cell culture system has limited high-resolution structures of parvovirus B19 (B19V) to virus-like particles (VLPs). In this study, we…

JCI - SARS-CoV-2 Delta and Omicron variants resist spike cleavage by human airway trypsin-like protease

Uncovering key players in gene silencing: Insights into plant growth and human diseases

Monash University biologists have shed light on the intricate molecular mechanisms that are responsible for gene silencing induced by expanded repeats in an international study published today in Nature Plants.

The Calpain-7 protease functions together with the ESCRT-III protein IST1 within the midbody to regulate the timing and completion of abscission

Biochemical, structural, imaging, and functional studies reveal how the ESCRT-III protein IST1 recruits the CAPN7 cysteine protease to midbodies, where its proteolytic activity is required for efficient abscission and NoCut checkpoint arrest.