We mostly play material made for older editions that I convert (right now we've been doing a AD&D adventure called Date of Expiration). One thing I always need to learn and relearn is to also convert over the XP values because older stuff's XP is all over the place.
Our campaign, #boatmode, is set in the Crowded Sea region of the Forgotten Realms; I have everything for 2e al-Qadim in hardcopy (and extras of Land of Fate, the best box). But we also heavily use Ghosts of Saltmarsh for 5e which I've ported over from Greyhawk to a li'l town between Jumlat and Gana named Safaq. We're 153 sessions in since we moved to this campaign setup and region; we've played other campaigns in the same continuity and on the same planet previously.