Yonatan Grad

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Associate Prof of Immunology & Infectious Diseases at Harvard TH Chan School of Public Health. Studying infectious diseases & how pathogens evolve and spread.
sites.sph.harvard.edu/grad-lab/
Yonatan GradJan 5, 2023
How does metabolic landscape influence the acquisition of antibiotic resistance? See this paper on N. gonorrhoeae by MD-PhD student Dan Rubin, which also shows the genetic basis for Ng's requirement for supplemental CO2: https://www.nature.com/articles/s41564-022-01282-x
CanB is a metabolic mediator of antibiotic resistance in Neisseria gonorrhoeae - Nature Microbiology

Metabolic variation via a single substitution in the β-carbonic anhydrase CanB determines CO2 dependence and influences fluoroquinolone resistance in Neisseria gonorrhoeae.

Nature