I use a 30% split keyboard as my daily driver for work as a software developer. I use a keymapping where holding the F key down turns the right side into a numpad plus some of the other punctuation, and holding D down gives me the shifted versions of all that. So I have to chord to get the esoteric symbols but I don't have to actually move my left hand from home row to chord. I don't think this is a very common way of doing things though. I'm not sure it's any better than using a bigger keyboard, but I'm used to it now.