So, after a few hours with Cities Skylines 2, what stands out to me the most - beyond the technical shortcomings and performance issues - is the complexity of the simulation and the level of detail in creating a virtual world.
If you showed a SimCity 4-obsessed me from 2005 this game, I would hardly be able to believe such level of accuracy in simulation would ever be possible.
What C:S2 does exceptionally well, is not upping the scale - but making the scale resonate a lot more than C:S did.