Phil Leung

@[email protected]
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20 Posts
githubgithub.com/proleu
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Phil LeungAug 22, 2023

Great summary of the hinge project

https://singularityhub.com/2023/08/22/ai-can-now-design-proteins-that-behave-like-biological-transistors/

AI Can Now Design Proteins That Behave Like Biological 'Transistors'

New designer proteins morph between two different forms—think a hinge in either an open or closed configuration—depending on an external biological “lock.”

Singularity Hub
Phil LeungAug 17, 2023
Huge thanks to all our coauthors, internal and external collaborators. This work was a monumental effort and it wouldn't have been possible on our own.
Show threadPhil LeungAug 17, 2023
In this way, these tiny proteins not so different from the hinges that we encounter every day in the macroscopic world :)
Show threadPhil LeungAug 17, 2023
One of the coolest parts of this paper is that we managed to obtain structures of these "hinges" in both states, both on their own and in the context of much larger protein assemblies
Show threadPhil LeungAug 17, 2023
In this work we designed proteins to switch their shapes contingent on an input (shown as a yellow helical peptide here)
Phil LeungAug 17, 2023
Excited to report the work I led with Flo at the UW Institute for Protein Design is now online in Science! https://www.science.org/doi/full/10.1126/science.adg7731
Phil LeungMar 31, 2023
Also, #ICYMI here's my #ProteinDesign #preprint with Flo: https://www.biorxiv.org/content/10.1101/2023.01.27.525968v1
Phil LeungMar 31, 2023
Defended yesterday! Big thank you to everyone who supported me along the way.
Phil LeungJan 2, 2023
great article on how much progress was made in molecular design and modeling in 2022: https://cen.acs.org/education/science-communication/CENs-Year-Chemistry-2022/100/i44 #proteinMPNN (thank you @dmikeando for notifying me the original link was broken - I am still very new to this site 😅 )
Show threadPhil LeungDec 30, 2022
Thanks to everyone who helped with this project and a special shoutout to Susana for really pushing this project forward and making it happen. We already have a lot of new exciting data that we're collecting for revisions.
And thanks to David Baker and Joseph Rogers for supervising this work and UW Institute for Protein Design for incredible computational, material, and administrative support. (11/11)