Mastodawn

(RSS) (Angew Chem) Multiplexed Tandem Mass Spectrometry Imaging Enables Large‐Scale Isomer Mapping and Annotation in Tissues: Parallel mass spectrometry imaging acquires high mass resolution and tandem mass spectrometry images from 108 isolation windows in a single run. Spatial similarity networking clusters product ions by spatial distribution, enabling annotation of isomers and isobars as demonstrated for phospholipids and oxidized… https://onlinelibrary.wiley.com/doi/10.1002/anie.202522119?af=R&utm_source=dlvr.it&utm_medium=mastodon (RSS) #AngewChem #MassSpecRSS

K K Murray (RSS)1h ago

(RSS) (Angew Chem) Single‐Injection Multi‐Omics Analysis by Direct Infusion Mass Spectrometry: A high-throughput direct infusion mass spectrometry platform, enabled by gas-phase ion mobility separation, supports single-injection analysis of peptides, polar metabolites, and lipids. Coupled with custom software, it identified ∽1,300 proteins and ∽600 metabolites in ∽4.3 minutes per sample, and demonstrated broad utility in macrophage… https://onlinelibrary.wiley.com/doi/10.1002/anie.202519836?af=R&utm_source=dlvr.it&utm_medium=mastodon (RSS) #AngewChem #MassSpecRSS

K K Murray (RSS)6h ago

(RSS) (BioRxiv All) Serum proteomics reveals distinct phenotypic signatures to IL-6 blockade between two immunotherapies: A recent clinical study tested the effects of two different monoclonal antibodies (mAbs) (siltuximab, anti-IL6; tocilizumab, anti-IL6R) on the fate and function of T-cells in people with type 1 diabetes. While both mAbs affect the response of T-cells to stimulation, they have very different, sometimes opposing mechanisms. Here,… https://www.biorxiv.org/content/10.64898/2026.03.27.712461v1?rss=1&utm_source=dlvr.it&utm_medium=mastodon #BioRxiv #MassSpecRSS

K K Murray (RSS)11h ago

(RSS) (JASMS) [ASAP] Mass Spectrometric Determination of Site-Specific O-Acetylation in Rhamnogalacturonan I Oligomers: Journal of the American Society for Mass SpectrometryDOI: 10.1021/jasms.5c00440 http://dx.doi.org/10.1021/jasms.5c00440?utm_source=dlvr.it&utm_medium=mastodon (RSS) #MassSpecRSS #JASMS

K K Murray (RSS)12h ago

(RSS) (BioRxiv All) In-source fragmentation in mass spectrometry-based proteomics: prevalence, impact, and strategies for mitigation: Peptide-level analyses are becoming increasingly popular in mass spectrometry-based proteomics and are being applied, for example, in immunopeptidomics, structural proteomics, and analyses of post-translational modifications. In such analyses, peptides that are not biologically meaningful but instead arise as… https://www.biorxiv.org/content/10.64898/2026.03.27.714398v1?rss=1&utm_source=dlvr.it&utm_medium=mastodon #BioRxiv #MassSpecRSS

K K Murray (RSS)12h ago

(RSS) (ACS Anal Chem) [ASAP] Vinyltrimethylsilane Chemical Ionization Tandem Mass Spectrometry Separates Methoxyphenylpiperazine Isomers: Analytical ChemistryDOI: 10.1021/acs.analchem.5c08125 http://dx.doi.org/10.1021/acs.analchem.5c08125?utm_source=dlvr.it&utm_medium=mastodon #MassSpecRSS #ACSAChem

K K Murray (RSS)13h ago

(RSS) (J Mass Spectrom) Ultra‐Performance Liquid Chromatography–Electrospray Ionization–Ion Trap Tandem Mass Spectrometry for Fragmentation of Cyclic Dipeptides: Methodology and Application to the Chemical Profiling of the Fungus Hormonema dematioides: Journal of Mass Spectrometry, Volume 61, Issue 4, April 2026. https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/jms.70055?af=R&utm_source=dlvr.it&utm_medium=mastodon #JMassSpectrom #MassSpecRSS

K K Murray (RSS)15h ago

(RSS) (J Sep Sci) Reduction of Matrix Effects in Liquid Chromatography‐Tandem Mass Spectrometry by a Dilution Approach for the Analysis of 245 Pesticide Residues in Selected Vegetables: ABSTRACT

Matrix effects in liquid chromatography-tandem mass spectrometry remain a significant challenge in pesticide residue analysis. Ion suppression can introduce uncertainty in quantification and adversely affect both precision and accuracy. To address this,… https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/jssc.70401?af=R&utm_source=dlvr.it&utm_medium=mastodon #JSepSci #MassSpecRSS

K K Murray (RSS)16h ago

(RSS) (J Sep Sci) Identification and Structural Elucidation of Galloylated B‐Type Procyanidins From Rumex obtusifolius L. Using Enzymatic Digestion, Phloroglucinolysis, and High‐Resolution Mass Spectrometry: ABSTRACT

Procyanidins from plant extracts demonstrate a broad spectrum of bioactive potential. In order to establish structure-activity relationships, it is necessary to fully determine the stereochemistry and substitution pattern.… https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/jssc.70396?af=R&utm_source=dlvr.it&utm_medium=mastodon #JSepSci #MassSpecRSS

K K Murray (RSS)18h ago

(RSS) (BioRxiv All) The phosphoS655 Alzheimer's Amyloid Precursor Protein (APP) interactome in neuronal differentiation: The Alzheimer's Amyloid Precursor Protein (APP) has determinant roles in neuronal development and function, both in its full-length conformation and as some of its proteolytic peptides, particularly secreted (s)APPa. Given that APP phosphorylation tightly regulates its trafficking, proteolysis, and protein-protein binding, it… https://www.biorxiv.org/content/10.64898/2026.03.26.714600v1?rss=1&utm_source=dlvr.it&utm_medium=mastodon #BioRxiv #MassSpecRSS