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Postdoc @Rockefeller, PhD @thecrick | All things B cells, endogenous retroviruses, and cancer | Semi-retired violinist | Canadian in NYC 🇨🇦🏳️‍🌈

(Thread)

1/ What is the physiological impact of dietary proteins on steady-state T cells? Nelson Vaz and Ana Faria, my undergrad mentors, wondered about this question for decades.

https://www.biorxiv.org/content/10.1101/2023.04.11.536475v1

CBC bails on Twitter.

'Our cross-species study indicates that scaling of cell size to ploidy is not due to abrupt changes in cell division timing, that different size scaling regimes occur during embryogenesis, and that the developmental program of Xenopus is remarkably consistent across a wide range of genome and egg sizes.'

https://www.cell.com/current-biology/fulltext/S0960-9822(23)00161-6

Dodecaploid Xenopus longipes provides insight into the emergence of size scaling relationships during development

Miller et al. examine the development of frog species of varying genome and egg sizes and observe that embryogenesis is characterized by distinct scaling regimes at the cellular and subcellular levels. Developmental timing is similar, despite differing nuclear-cytoplasmic ratios, with genome to cell size scaling emerging at the tadpole stage.

Current Biology

"When The New York Times, often so careful to avoid offending conservatives, is pointing out the anti-abortion rhetoric in your ruling, where you eschew the scientific terms for a penchant for militant pro-life language, you’re clearly far out on the fringes of your profession."

@gregggonsalves

https://www.thenation.com/article/society/gop-judges-abortion-guns/

The GOP’s Fanatical Judges Are Putting Our Lives in Danger

Recent rulings on Obamacare and abortion show a judiciary that is willing to imperil the lives of millions in pursuit of its radical agenda.

The Nation

Very excited to share my PhD work on B cell responses in lung cancer!

Antibodies to endogenous retroviruses promote lung cancer immunotherapy

https://www.nature.com/articles/s41586-023-05771-9

Antibodies against endogenous retroviruses promote lung cancer immunotherapy - Nature

In lung adenocarcinoma, antibodies against endogenous retroviruses promote anti-tumour activity, and expression of endogenous retroviruses can predict outcomes of immunotherapy.

Nature

Sarbecoviruses related to SARS-CoV-2: structures of 12 glycan shields. Many diffrences in the processing state of glycans. The S2 domain more conserved, many High-Man, so maybe S2 can be a candidate for a pan-coronavirus vaccine?

https://tinyurl.com/3h3f2n75

#glycotime

Further proof that transposons are absolutely amazing:

'A retrotransposon insertion in the Mao1 promoter results in erect pubescence and higher yield in soybean'

So much space for domesticating our own transposons...

https://www.pnas.org/doi/abs/10.1073/pnas.2210791120

Thrilled that my kids book "Birds (A Day in the Life)" is out today with Neon Squid Press! https://neonsquidbooks.com/uk/books/birds-a-day-in-the-life/
Birds (A Day in the Life)

Set over a 24-hour period, meet speedy ostriches, tiny hummingbirds, and majestic eagles in this kids’ non-fiction book about the coolest birds in the world.

Neon Squid
RT @BrodskyIgor
Huge congrats to co-1st authors DanielSorobetea and @RinaDoesScience @CAMBUpenn on this lovely story out today @NatureMicrobiol in which we uncovered intestinal pyogranulomas forming acutely during Yersinia pseudotb infection! https://www.nature.com/articles/s41564-023-01338-6
Inflammatory monocytes promote granuloma control of Yersinia infection - Nature Microbiology

Enteric Yersinia pseudotuberculosis infection is contained by host inflammatory monocyte-driven pyogranuloma formation to counter bacterial YopH-dependent anti-neutrophil activity.

Nature
This improved my day
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RT @bielleogy
Ok I'm outing myself here but there was forgotten beef soup in our fridge we just cleaned it out and it was BLUE?!?!? Wtf contam would make it blue??? Like BRIGHT blue!! 🤢🤮 Even w/ all my years in micro I'm not handling this well.
https://twitter.com/bielleogy/status/1630806917085032450
Tweet / Twitter

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