I'm very happy to find myself in my lovely new Mastodon home here on https://biologists.social/about, the server for biologists by biologists
If you'd like to join me here, try this useful guide on how to migrate your account (h/t @steveroyle). You will automatically keep all your followers.
Spread the word!
https://allthings.how/how-to-migrate-from-one-mastodon-server-to-another/
All you need to know about how rentier #capitalism works in one bit of data:
The UK's water firms were privatised without any outstanding debts over thirty years ago.... now, the privatised #infrastructure (regional) #monopolies have around £62bn in debt, but are still failing to deliver an adequate service.
If that debt has not been used to invest sufficiently in the #infrastructure, which the firms now (grudgingly) admit,, you might wonder where has it gone?
I leave that for you to guess!
'This is a vision of hell. It is also a glimpse of the future. The Institute for Economics and Peace has estimated that by the middle of the century more than a billion people will be at risk of displacement because of ecological threats.'
One of the most illuminating stories that I read about AI. How it is extracting brain power from a huge army of annotators, that need to be more and more specialized as the models "evolve". Worth reading.
Rewilding Portugal: the valley that waited 400 years for the cows to come home
One of those papers that makes one go running to the bench with new ideas to test.
So good to revisit the "old" gene-gating model" in the context of super-enhancers and chromatin organization.Great work.
High-precision mapping of nuclear pore-chromatin interactions reveals new principles of genome organization at the nuclear envelope https://doi.org/10.7554/eLife.87462.1
"Significant different in length after the trial were observed between live feed and commercial feeds. Similarly, differences in rate of regeneration were observed. ...
Our data highlights the need for establishing a standardized diet for regeneration studies to improve research reproducibility."
"background selection (purifying selection on deleterious mutations ) is the dominant mode of linked selection in humans, with marked effects on diversity levels throughout autosomes."
Broad-scale variation in human genetic diversity levels is predicted by purifying selection on coding and non-coding elements https://doi.org/10.7554/eLife.76065
"...by activating the YAP/TAZ-adrenomedullin cascade, mechanostimulation improves erectile function in PDE5i nonrespondent ED model rats and mice.
Furthermore, using clinical retrospective observational data, we found that mechanostimulation significantly promotes erectile function in patients irrespective of PDE5i use."
Phosphodiesterase type 5 inhibitors (PDE5is) are used to treat erectile dysfunction, however, not all patients respond to PDE5i treatment. Here the authors report that YAP/TAZ activity contributes to erectile dysfunction and targeting YAP/TAZ improves erectile function in a PDE5i non-respondent rat model.
Sally Lowell
Emeritus Prof Christopher May
Thiago Carvalho
