| Pronouns | He/Him |
| Code | https://github.com/diazale/ |
Our latest on the dramatic impact of colonial admixture and slave trade in South Africa. We identify strong male founder effects and displacement of Khoe-San peoples. 🇿🇦
Thinking about kinds of analysis errors. There are errors of design, doing the wrong analysis intentionally, & also errors of execution, doing the wrong analysis by accident. Like this 2016 example in which country codes entered as continuous by accident. https://www.cell.com/current-biology/fulltext/S0960-9822(16)30670-4
Working in ways to prevent such errors is important. I simulate synthetic data to validate my analysis. Even in simple contexts, accidents can happen. Because computers suck and are out to get us.
Out now! We study genetic structure in large biobanks using topological data analysis via UMAP and HDBSCAN.
This approach is fast, easy-to-use, fits into existing pipelines, uses data you already have, and is downright fascinating.
Our pre-print is on bioRxiv and we have our code with a demo up on github: https://github.com/diazale/topstrat
We present VIPRS, a fast and accurate variational Bayesian method for estimating polygenic risk scores from genome-wide association study (GWAS) data. The method is shown to be robust and competitively accurate against popular baselines and scales well to dense genotype array data.
It's official: it won't open this season, for the first time ever. 😔
It was clear this would happen eventually, but I didn't think it would be this soon.
SFGravel
HennLab
Richard McElreath 🦔