Ernesto de Bernardis

@[email protected]
13 Followers
17 Following
31 Posts
Lazy but curious (curious but lazy), cog in the wheel, armchair wannabe researcher, addictions doc, pharmacologist, national board of www.sitd.it
orcidhttps://orcid.org/0000-0002-6809-4096
home pagehttp://www.debernardis.it
On Twitter@debe
Ernesto de BernardisNov 24, 2022
Adrian BowyerNov 24, 2022
RT @SteveStuWill
Wow! Scientists have observed a single-cell alga evolve in real time into a multicellular organism. The transition took around a year and was caused by the introduction of a predator into the environment. https://nature.com/articles/s41598-019-39558-8
Ernesto de BernardisNov 19, 2022
Deh HaaghNov 11, 2022
Ernesto de BernardisNov 18, 2022
Periodic toot to search for people interested in #addictionmed #addiction medicine - please reply! 😁
Ernesto de BernardisNov 7, 2022
@manlius maybe medications presently defined as psychoplastogens (a sterilized, industry term for some hallucinogenics and dissociatives in trial for mental disorders) could be taken into consideration for counteracting such pruning
Ernesto de BernardisNov 6, 2022

@oneabstractaday #oneabstractaday

"Variables associated with COVID-19 infection
Only smoking was associated with a decreased risk of SARS-CoV-2 infection (OR 0.491; 95% CI 0.275–0.878; p = 0.017). No other factors, neither demographic, clinical, disability, comorbidity, nor treatment was associated with the risk of SARS-CoV-2 infection"

https://www.frontiersin.org/articles/10.3389/fneur.2022.1001429/full

@oneabstractaday #oneabstractaday

Ernesto de BernardisMay 25, 2022

@oneabstractaday

Fascinating review which could explain the difference between dopaminergic antidepressants and anorexiants (which don't induce addiction, with the notable exception of amineptine) and cocaine.
Apparently there was no follow-up (but still cited).

https://pubmed.ncbi.nlm.nih.gov/24953830/

Dopamine reuptake transporter (DAT) "inverse agonism"--a novel hypothesis to explain the enigmatic pharmacology of cocaine - PubMed

The long held view is cocaine's pharmacological effects are mediated by monoamine reuptake inhibition. However, drugs with rapid brain penetration like sibutramine, bupropion, mazindol and tesofensine, which are equal to or more potent than cocaine as dopamine reuptake inhibitors, produce no discern …

PubMed
Ernesto de BernardisMay 12, 2022

Welcome to Hotel Elsevier: you can check-out any time you like … not - Eiko Fried

A journey by Robin Kok and Eiko Fried trying to understand what private data Elsevier collects; what private data Elsevier sells; and what to do about it.

https://eiko-fried.com/welcome-to-hotel-elsevier-you-can-check-out-any-time-you-like-not/

Welcome to Hotel Elsevier: you can check-out any time you like … not » Eiko Fried

A journey by Robin Kok and Eiko Fried trying to understand what private data Elsevier collects; what private data Elsevier sells; and what to do about it.

Eiko Fried
Ernesto de BernardisMay 12, 2022

Welcome to Hotel Elsevier: you can check-out any time you like … not - Eiko Fried

A journey by Robin Kok and Eiko Fried trying to understand what private data Elsevier collects; what private data Elsevier sells; and what to do about it.

https://eiko-fried.com/welcome-to-hotel-elsevier-you-can-check-out-any-time-you-like-not/

Welcome to Hotel Elsevier: you can check-out any time you like … not » Eiko Fried

A journey by Robin Kok and Eiko Fried trying to understand what private data Elsevier collects; what private data Elsevier sells; and what to do about it.

Eiko Fried
Ernesto de BernardisMay 9, 2022

@oneabstractaday

"In the largest US study to date on smoking and COVID-19, current and former smoking showed lower risk of SARS-CoV-2 infection than never-smoking, while a history of smoking was associated with higher risk of severe COVID-19."

"Current smoking was associated with lower adjusted rates of SARS-CoV-2 infection (aHR=0.64 95%CI:0.61-0.67)…”

https://academic.oup.com/ntr/advance-article-abstract/doi/10.1093/ntr/ntac090/6562890

Cigarette Smoking and Risk of SARS-CoV-2 infection and Disease Severity Among Adults in an Integrated Health Care System in California

AbstractIntroduction. The relationship between cigarette smoking status and SARS-CoV-2 infection and coronavirus disease 2019 (COVID-19) severity is highly deba

OUP Academic
Ernesto de BernardisMay 6, 2022

@oneabstractaday

"Bromhexine is an effective, non-invasive, and affordable agent with a low side-effect profile to prevent symptomatic COVID-19. Early use of bromhexine potentially provides another layer of protection and hence it can play a prominent role in ending the pandemic especially given the emergence of new variants and the vaccination challenges faced by developing countries."

https://www.researchsquare.com/article/rs-1612290/v1

Bromhexine, for post exposure COVID-19 prophylaxis: A Randomized, Double-Blind, Placebo Control Trial

Purpose Limited number of medications are available for the post-exposure prophylaxis of COVID-19 infection. Whether bromhexine can prevent or mitigate symptomatic infection after virus exposure is undetermined.Methods A multi-center randomized; double-blind, placebo-c...