Assembly and reasoning over semantic mappings at scale for biomedical data integration

Motivation: Hundreds of resources assign identifiers to biomedical concepts including genes, small molecules, biological processes, diseases, and cell types. Often, these resources overlap by assigning identifiers to the same or related concepts. This creates a data interoperability bottleneck, as integrating data sets and knowledge bases that use identifiers for the same concepts from different resources require such identifiers to be mapped to each other. However, available mappings are incomplete and fragmented across individual resources, motivating their large-scale integration. Results: We developed SeMRA, a software tool that integrates mappings from multiple sources into a graph data structure. Using graph algorithms, it infers missing mappings implied by available ones while keeping track of provenance and confidence. This allows connecting identifier spaces between which direct mapping was previously not possible. SeMRA is customizable and takes a declarative specification as input describing sources to integrate with additional configuration parameters. We make available an aggregated mappings resource produced by SeMRA consisting of 43.4 million mappings from 127 sources that jointly cover identifiers from 445 ontologies and databases. We also describe benchmarks on specific use cases such as integrating mappings between resources cataloging diseases or cell types. Availability: The code is available under the MIT license at https://github.com/biopragmatics/semra. The mappings database assembled by SeMRA is available at https://zenodo.org/records/15208251. ### Competing Interest Statement The authors have declared no competing interest.

Data Standardization and Integration with the Bioregistry at Biocuration 2025

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Biocuration Community Survey 2025

This survey aims to gather and analyze information about the field of biocuration. This survey is being conducted by the International Society for Biocuration (ISB) to identify potential gaps or inequities among biocurators and to identify areas where the ISB may be able to take actions to improve awareness of biocuration. This is a follow-up with our community to assess the progress made since the we began surveying the community in 2017. The results from past surveys are available here: https://www.biocuration.org/dissemination/survey-results/ (see ISB Career Description Survey Results). The resulting data will be aggregated and analyzed and shared with the community. No identifying information will be revealed in reporting results of this survey. Thank you for your participation.