You can do this during fights. The question is who will control the party when just walking around and talking to NPCs or exploring the world. Who will make the story changing decisions?
Also things like leveling up your character, or changing equipment may be more painful depending on everyone’s patience. Being in a multiplayer campaign is already quite the commitment but having to wait for your turn at the controller to change equipment or spells might make it unenjoyable.
I really enjoyed The Witching Hour by Loeb and Bachalo. I guess it’s been 20 years or so now. I’ll have to go dig up my copy as it’s due for a reread.
Yes I think it would be frustrating if you are playing with random people. Learning is part of the gameplay so experienced players will have to teach / direct new players. For example, my group died multiple times when we had to deal with radiation just because we didn’t know what to do with irradiated material.
On mic is absolutely a requirement as coordination is a major emphasis. Granted the game is still in active development. But from what I’ve heard, the new features will require even more teamwork and coordination.
I.e. you can have fire on one side of the ship and radiation on the other, whilst in the middle of a dogfight. These elements are scaled to the size of your party and difficulty level though. If you play solo, you have an onboard bot that helps and you don’t have to juggle as much.