Then came the 🔥 question: could we leverage this method to discover novel antiviral factors in humans?

The answer is yes. We identified a family of ISGs, GIMAPs, resembling components of the Eleos system, and showed that they’re active against Herpes and Sindbis virus!

And… we found thousands of hits 🤯.

But are these eukaryotic homologs involved in immunity ?

To tackle this, we focused our analysis on humans, where immunity has been deeply studied and launched a great collaboration with Enzo Poirier.