Fascinating work revealing cell-autonomous (pre-existing mutations) and non-cell autonomous (inflammatory microenvironment caused by PM2.5-activated macrophages) mechanisms of lung cancers!
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RT @CharlesSwanton
Today our important study on air pollutants in the promotion of lung cancer has been published in @Nature led by @WillHilliam @LimEmilia @DrClareWeeden @SwantonLab ...Thread below🧵https://www.nature.com/articles/s41586-023-…
https://twitter.com/CharlesSwanton/status/1643647031997546497

I should also note that Venetoclax can kill Bax/Bak1 double KO and even Bcl2 KO AML cells in a mitochondrial apoptosis-independent manner (Fig. S1g and h). This has been previously proposed by others, such as @MitosRUs.
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RT @TMHemOnc
1/4 Thrilled to announce our latest paper published in @LeukemiaJnl, now accessible here: https://rdcu.be/c8t7q. Our findings reveal that a mitochondrial E3 ubiquitin ligase complex, consisting of MARCH5, …
https://twitter.com/TMHemOnc/status/1640346961420378114

One of the best meetings in the field of hematology/oncology research 😀
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RT @FASEBorg
Register now to learn about new blood disease research at the Hematologic Malignancies Conference on Aug 6. Join you colleagues and tap the proverbial vein of knowledge in Southbridge, Massachusetts! #HMCSRC @theaglab @The_Will_Lab
Register:
https://bit.ly/3JPB0aT
https://twitter.com/FASEBorg/status/1638163555861032960

Why not in Japan? @PMDA_JPN
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RT @AML_Hub
🚨 NEWS 🚨
Oral ivosidenib, an IDH1 inhibitor, receives a positive opinion from the CHMP of the EMA for the treatment of patients with IDH1-mutated AML. This opinion is based on data from the AGILE trial.
https://loom.ly/7yv6z94
#leusm #mednews
https://twitter.com/AML_Hub/status/1630569392202194944

RT @erturklab
Imagine you could stain whole adult mice with standard IgG antibodies. What you couldn't do! We present wildDISCO technology for this🤗, creating the first whole body vascular, lymphatic, and nerve atlases. By @HongchengM @jieluo692 https://www.biorxiv.org/content/10.1101/2023.02.17.528921v1.full.pdf 🧵👇🏼(turn on the sound)

RT @CraigMCrews
Ever try to drug an oncoprotein driver only to have the tumor lose its dependency on it and become drug resistant? Introducing RIPTACs (Regulated Induced Proximity Targeting Chimeras) in collaboration with Halda Therapeutics.

I strongly recommend you to put a AirTag in your suitcase when traveling internationally. It is very useful ...for example, I know my suitcase is still in Dallas 😭 (I returned to Japan last night)

Enjoyed #ASH2022 day (science) and night (food/music) ! It was so great to see many friends at the meeting!

RT @brummendorf
Fantastic kick-off talk at the stem cell biology session of #ESHBMFS2022 by Markus Manz from ⁦@Unispital_USZ⁩ followed by ⁦@ColemanLindsley⁩ and Peter Campbell and Stephen Ting … amazing science and superb discussions ⁦@ESHaematology⁩