Keith Hornberger

236 Followers
41 Following
180 Posts
Exec. director, medicinal chemistry @ArvinasInc | PhD @Columbia | hiker | beer & cocktail enthusiast | he/him/huz/dad | dreaming of @SedonaAZ | all posts my own
bloghttp://krhornberger.substack.com/
A new Ramblings post is up on the blog. This month: the simplest design vs. the best one, the value of collaboration in ideation, some nuance on AI/ML, the importance of getting down to work, and more. Check it out! πŸ“š
https://open.substack.com/pub/krhornberger/p/ramblings-august-2024
Ramblings: August 2024

29 September 2024

Med Chem Ramblings
A new edition of Ramblings is up on the blog. This month I cover the power of GRCs, how LinkedIn is (mis)used, the intrusion of proper nouns into science, a bit more on ML model training, and more. Check it out! πŸ“š
https://krhornberger.substack.com/p/ramblings-july-2024
Ramblings: July 2024

25 August 2024

Med Chem Ramblings
A new Ramblings post is up on the blog. This month I cover: some of the downsides of industry life, time management, the value of saying thanks, the value of knowing what you don’t know, and more - check it out! πŸ“š
https://krhornberger.substack.com/p/ramblings-june-2024
Ramblings: June 2024

7 August 2024

Med Chem Ramblings
For your Sunday coffee β˜•οΈ a new edition of Ramblings is up on the blog. This month I cover: making a good slide deck, training sets for AI/ML models, the burden of clinical trial failure rates, the importance of good pharmacology and doing control experiments in the literature, and more. Check it out!
https://krhornberger.substack.com/p/ramblings-may-2024
Ramblings: May 2024

23 June 2024

Med Chem Ramblings
For your Sunday coffee β˜•οΈ a new Ramblings is up on the blog. This month: sunny San Diego, volume of distribution, drug discovery slang, building your leadership skills, the art of asking the right questions, sig figs, scientific fraud, and more. Link below β€” check it out! πŸ“š
https://krhornberger.substack.com/p/ramblings-april-2024
Ramblings: April 2024

19 May 2024

Med Chem Ramblings
A new edition of Ramblings is up on Substack. This month I cover industrial & academic value systems, bonding over broken glassware, what a β€œdrug” is, editorializing in manuscripts, tiki drinks 🍹, and more. Check it out!
https://krhornberger.substack.com/p/ramblings-march-2024
Ramblings: March 2024

28 April 2024

Med Chem Ramblings
For your Easter 🐣 Sunday coffee β˜•οΈ a new edition of Ramblings is up on Substack. This month I cover work-life balance, layoff survival, weak ligands, irreproducible results, lifelong learning, the retat stemm cell debacle, and more. Check it out!
https://krhornberger.substack.com/p/ramblings-february-2024
Ramblings: February 2024

31 March 2024

Med Chem Ramblings
For your Sunday coffee β˜•οΈ a new Ramblings post is now up on my blog. This month I cover: Jensen Huang at JPM24, the rate-limiting step of drug discovery, ways to challenge your thinking, training and career growth for medicinal chemists, and more. Check it out!
https://krhornberger.substack.com/p/ramblings-january-2024
Ramblings: January 2024

10 March 2024

Med Chem Ramblings

So I've updated it to show a little bit of the difference between the well-stirred and parallel tube models, with more of a lean toward people starting with in vitro data, and appropriately renaming it. Link is here.

Btw, @KRHornberger , I dunno if your usual audience might find this a useful little tool or if there's any small changes you think would be helpful.

https://jtsdmpk.shinyapps.io/HepaticClearance/

Hepatic Clearance Models

Nice overview on properties of orally bioavailable degraders from the Caron and Kihlberg labs. Thanks for mentioning our work too! ☺️
https://www.sciencedirect.com/science/article/pii/S1359644624000424