Avoiding spoilers, one of the major quests has you approach and help someone fight some monsters. In that same place there is a skeleton with a key in it for a different side quest.
After you finish fighting the monsters, a dialog cutscene triggers with the person you just helped, but there is a small window of time between the combat ending and the dialog cutscene starting when you actually loot.
I actually managed to soft lock a side quest in The Witcher 3 recently. If you loot a container right as a cutscene begins, the item will be removed from the container but not put into your inventory.
I managed to do this with a key (by mistake) and almost lost around 25 hours of gameplay lol.
Initially I too felt like I was missing out on content, but the more time I spent away from Reddit the easier it feels to stay away.
I have accepted that I will not get certain kinds of content and communities, but that's a sacrifice I'm willing to make for Kbin / Lemmy. And I believe that slowly, eventually we'll have the quality of the communities we had on Reddit. It just takes time.