Matt BlazeGrand Central Terminal (with Chrysler Building Photobombing), NYC, 2017.
All the pixels, but no food court or Apple store, at https://www.flickr.com/photos/mattblaze/31933507513
Cori Bargmann
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- 62 Posts
Genetics, neuroscience
Simple Sabotage Field ManualGive lengthy and incomprehensible explanations when questioned.
Rockefeller University is conducting a faculty search for exceptional biomedical scientists. Spread the word!
https://www.nature.com/naturecareers/job/12843635/faculty-positions-at-the-rockefeller-university/?LinkSource=PremiumListing
https://www.nature.com/naturecareers/job/12843635/faculty-positions-at-the-rockefeller-university/?LinkSource=PremiumListing
Tim HergertTom Lehrer wasn't just a satirist or a musician. He as a comedian who could quietly tell a joke and wait more than SIXTY YEARS for the payoff.
That's dedication to craft.
We lost an icon.
From:
https://bsky.app/profile/opalescentopal.bsky.social/post/3luxxx2a2f623
Ben WaberThe model collapse paper is now officially published, in Nature no less: https://www.nature.com/articles/s41586-024-07566-y
AI models collapse when trained on recursively generated data - Nature
Analysis shows that indiscriminately training generative artificial intelligence on real and generated content, usually done by scraping data from the Internet, can lead to a collapse in the ability of the models to generate diverse high-quality output.
Thiago CarvalhoA very interesting role for a cytidine deaminase: a single base RNA modification that converts a protease to a growth factor acting in regeneration in the C elegans nervous system.
https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1011367
A cytidine deaminase regulates axon regeneration by modulating the functions of the Caenorhabditis elegans HGF/plasminogen family protein SVH-1
Author summary The axon regeneration pathway in C. elegans is activated by SVH-1, a growth factor that belongs to the HGF/plasminogen family. SVH-1 is a dual-functional factor that promotes axon regeneration as an HGF-like growth factor and regulates development as a plasminogen-like protease. It is crucial to understand the mechanism by which SVH-1 transforms from a protease to a growth factor during axon regeneration. In this study, we demonstrate that CDD-2, a cytidine deaminase, is critical for converting SVH-1 function from a protease to a growth factor by modifying svh-1 mRNA.
Lots of cool things Margaret learned from making/studying different conditions and mutants: hermaphrodites become cooperative in mating once they run out of sperm, or if they never make sperm; males and females use the same neurons to chemotax to the opposite sex. And another hermaphrodite species becomes even more female-like in the response to males when sperm-depleted. Their nervous systems are simple, but these latent and flexible behaviors teach us not to underestimate our model organisms.
Margaret compared pairs of closely related species where one species is male/female and one is male/hermaphrodite. She found that females are highly motivated to mate. They chemotax to males, and cooperate with males during mating. They get less cooperative after they’ve been mated, though. Hermaphrodites are unmotivated and uncooperative. But why? Two reasons — they’ve lost a specific olfactory response, and their own sperm makes them think they’re “mated”.
I’m excited that Margaret Ebert’s postdoctoral work is out in Current Biology! This paper explores the ways mating behaviors differ between females and hermaphrodites. https://urldefense.proofpoint.com/v2/url?u=https-3A__authors.elsevier.com_sd_article_S0960-2D9822-2824-2900087-2D3&d=DwMFaQ&c=JeTkUgVztGMmhKYjxsy2rfoWYibK1YmxXez1G3oNStg&r=kGWJErNJo7fN0L1-etpxjVyd5wpAuwGrxU_YWX1OYbA&m=vg0aRq2g8QSFvw41XER_EOdynW_Rl6bIOXu816Td43Vp566oGs9-FLg30F0TfvWG&s=_9yvee-VCP_XX34gqubIBIDwpdEabPDP77bzxfX4X0s&e=
Boris BarbourAnnouncing the 2024 edition of the Paris Spring School for Optical Imaging and Electrophysiological Recording in Neuroscience
15-28 May 2024
Application deadline Feb 1st.
Boosts appreciated.