Skeletal muscle is the only interface our CNS has with the outside world. So it stands to reason that the CNS communicates with skeletal muscle through multiple mechanisms. In our new preprint https://www.biorxiv.org/content/10.1101/2020.12.20.423533v2 we show neuroinflammation activates a brain-muscle signaling axis that regulates muscle performance #myotwitter #muscle