geeknikAutism splits into two replicable biological subtypes: hypoconnectivity tied to synaptic dysfunction, hyperconnectivity to immune pathways. Validated across mice and ~2,000 humans. A real target for subtype-specific treatment.
https://pubmed.ncbi.nlm.nih.gov/42141307/
https://pubmed.ncbi.nlm.nih.gov/42141307/
Autism subtypes identified using cross-species functional connectivity analyses - PubMed
It is often assumed that phenotypic heterogeneity in autism reflects underlying pathobiological variation. However, direct evidence supporting this link is lacking. Leveraging cross-species functional neuroimaging, we show that brain dysconnectivity patterns in autism can be parsed into biologically …