For #tagspub, I've done more fine-tuning with user domain blocks.
I have to admit that I've been surprised at how soft user domain blocks are in Mastodon. I added a bug report for one behaviour that I thought was unclear: a signed request from a blocked domain for your user profile will succeed. https://github.com/mastodon/mastodon/issues/39318 It may get dismissed as works as designed; I don't know.
User domain blocks also don't keep your content from going out to blocked relays; see here https://github.com/mastodon/mastodon/issues/39293 .

Signed GET from user blocked domain to actor is incorrectly successful · Issue #39318 · mastodon/mastodon
Steps to reproduce the problem [email protected] blocks domain other.example [email protected] fetches https://mastodon.example/user/user1 with a signature and Accept: application/activity+j...