On a Google Mobile Services OS, Play services is built into the OS as a highly privileged component with immense access and handles work across profiles.
Sandboxed Google Play are regular sandboxed apps without any special access. Each installation in a separate profile is entirely independent.
@morganist @fazalmajid Android has a standard feature for disabling 2G on carriers permitting it which is made available for all carriers on GrapheneOS.
GrapheneOS adds a much better feature predating the 2G toggle for using 4G-only, 4G/5G-only or 5G-only. The lowest attack surface option is 4G-only where you don't have the attack surface of legacy 2G or 3G along with not having the more complex 5G. 4G/5G-only just gets rid of 2G/3G and 5G-only is only available on carriers with Standalone 5G.