Oddly pairing Microbe C++ with #gtk (gtk4) directly produces far better cross-platform results than either #vala #mono or C++ with #Qt and does so while producing tiny executables. Of course, the idea of doing any desktop applications while #blind is rather amusing, too.
Something like Microbe might pair very well with #LVGL too, producing an embedded ui environment potentially cleaner than #QtQuick for most use cases while having far less execution overhead.