Alice Frolov⚡ SIRT1: NAD+-dependent deacetylase linking energy status to longevity
Caloric restriction → ↑ NAD+ → SIRT1 activation → deacetylates FOXO, p53, PGC-1α
Results: enhanced DNA repair, mitochondrial health, stress resistance
Why NAD+ declines with age = why SIRT1 activity drops
