CADTH Reimbursement Reviews: ITC and NMA Evidence Standards for Canadian Market Access

Canada’s CADTH Reimbursement Review (CRR) process imposes distinct indirect treatment comparison (ITC) and network meta-analysis (NMA) evidence standards that differ materially from EMA, NICE, and G-BA requirements. This playbook decodes CADTH’s pharmacoeconomic guidelines, the expert review committee’s approach to unanchored matching-adjusted indirect comparisons, and the evidence-synthesis quality thresholds that determine whether a reimbursement recommendation is positive, conditional, or...