Vertical Mouse Update: It's fine. I got used to it in about four minutes. If you've been considering getting one but are worried it will feel too weird, it will not

@jalefkowit former physical therapist here... one word of caution about a vertical mouse. It gives your wrist and hand a break, but they're harder on your neck and shoulder, especially if you're doing precision work.

You can drive a conventional mouse entirely with your hand without any shoulder movement. You can still rely mostly on hand movements with a vertical mouse, but you're more likely to activate shoulder muscles too. For many people a vertical mouse is good for a change of pace, but might not be a permanent replacement.